Endocrine Abstracts

The enzyme dipeptidyl peptidase-IV (DPP-IV) is expressed by gut epithelial cells. DPP-IV cleaves X-proline dipeptides from the N-terminus of polypeptide hormones including GLP-1, GIP and PYY. DPP-IV causes a deactivation of the incretin hormones GLP-1 and GIP, whereas conversely, by converting PYY1–36 to PYY3–36 it allows specific activation of the Y2 receptors in the arcuate nucleus of the hypothalamus leading to hypophagia. Infused PYY3–36 has been ...